IMEDEEN Prime^TM - CLINICAL AND SCIENTIFIC STUDIES

1. EFFECT OF A NOVEL DIETARY SUPPLEMENT ON SKIN-AGING IN POSTMENOPAUSAL WOMEN.
(Published in European Journal of Clinical Nutrition 2006; 1-6.)

The aim of the study was to quantify the effects of IMEDEEN on post-menopausal skin. The study ran over a 6 month period and included 81 post-menopausal women aged 45-65, 30% of who were also taking HRT [hormone replacement therapy] . Thirty-eight participants received Imedeen Prime and 43 took a placebo. The results of both the objective measurements by dermatologists and the self-assessment by participants were significant. The report concluded that when taken twice daily over a 6 month period Imedeen Prime visibly improves the appearance and condition of post-menopausal skin and has been clinically and scientifically shown to:
66% of the women interviewed who experienced positive results said that their friends and family had also commented on the improvements to their skin.

2. CELLULAR PROTECTION BY NATURAL ANTIOXIDANTS IN CULTURED SKIN CELLS.
(Published in Free Radical Biology & Medicine 37: Supplement 1, S43, 2004)

The aim of the study was to find the best combination of antioxidants that would protect skin cells against UV damage and to document such effect.
An in-vitro study was carried out on the ViTea® protection complex to assess the increased defence against free radical damage. Skin fibroblasts were cultured under standard conditions. One culture was treated with the ViTea® Complex, the other was used as a control. Both cultures were irradiated in parallel with UV light. Multiple methods were used to analyse the extent of oxidative damage on the skin cells and measure the production of free radicals in both cultures.

The results show that the ViTea® complex minimises the amount of UV damage in skin cells. It decreases the amount of free radicals produced in skin fibroblasts and reduces the damage caused by UV radiation in essential building blocks such as lipids and DNA.

3. SUPPLEMENTATION WITH A COMPLEX OF ACTIVE NUTRIENTS IMPROVED DERMAL AND EPIDERMAL CHARACTERISTICS IN SKIN EQUIVALENTS GENERATED FROM FIBROBLASTS FROM YOUNG OR AGED DONORS.

The aim of the study was to examine the effect of IMEDEEN ingredients on quality and structure of dermis and epidermis in reconstructed human skin equivalent generated from skin cells of a 49 year old female. The skin equivalents were treated with the Imedeen Prime active ingredients and a control group was cultured in parallel without treatment.

Although both the young and the old skin equivalents showed that treatment with Imedeen Prime improved the quality and structure of both the dermis and epidermis versus the control cultures, the results for the aged skin equivalent were much more impressive than those for the young skin and showed a greater increase in dermal density, higher production levels of both collagen and elastin and an improved epidermal structure. Moreover treatment with Imedeen Prime prolonged the life span of both young and aged skin equivalents, clearly demonstrating the anti-ageing effect of the active ingredients.